Title : Expression of the SNAI2 transcriptional repressor is regulated by C16-ceramide.

Pub. Date : 2019

PMID : 30836822






8 Functional Relationships(s)
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1 Expression of the SNAI2 transcriptional repressor is regulated by C16-ceramide. N-palmitoylsphingosine snail family transcriptional repressor 2 Homo sapiens
2 Ceramide synthase 6 (CerS6) is an enzyme that preferentially generates pro-apoptotic C16-ceramide in the sphingolipid metabolic pathway. N-palmitoylsphingosine ceramide synthase 6 Homo sapiens
3 Ceramide synthase 6 (CerS6) is an enzyme that preferentially generates pro-apoptotic C16-ceramide in the sphingolipid metabolic pathway. N-palmitoylsphingosine ceramide synthase 6 Homo sapiens
4 shRNA against CerS5, which like CerS6 preferentially generates C16-ceramide, also decreased transcriptional activation of SNAI2, suggesting a role for C16-ceramide rather than a specific enzyme in the regulation of this transcription factor. N-palmitoylsphingosine ceramide synthase 5 Homo sapiens
5 shRNA against CerS5, which like CerS6 preferentially generates C16-ceramide, also decreased transcriptional activation of SNAI2, suggesting a role for C16-ceramide rather than a specific enzyme in the regulation of this transcription factor. N-palmitoylsphingosine ceramide synthase 6 Homo sapiens
6 shRNA against CerS5, which like CerS6 preferentially generates C16-ceramide, also decreased transcriptional activation of SNAI2, suggesting a role for C16-ceramide rather than a specific enzyme in the regulation of this transcription factor. N-palmitoylsphingosine ceramide synthase 5 Homo sapiens
7 shRNA against CerS5, which like CerS6 preferentially generates C16-ceramide, also decreased transcriptional activation of SNAI2, suggesting a role for C16-ceramide rather than a specific enzyme in the regulation of this transcription factor. N-palmitoylsphingosine snail family transcriptional repressor 2 Homo sapiens
8 In summary, our study identifies SNAI2 as a novel target whose expression can be influenced by C16-ceramide levels. N-palmitoylsphingosine snail family transcriptional repressor 2 Homo sapiens