Pub. Date : 1995 Oct 1
PMID : 7574728
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. | isopentyl alcohol | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 3 | Isopentanol, the major higher chain alcohol in alcoholic beverages, also induced CYP3A and CYP2E1. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Isopentanol, the major higher chain alcohol in alcoholic beverages, also induced CYP3A and CYP2E1. | isopentyl alcohol | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 5 | Ethanol and isopentanol were each more potent and more effective at inducing CYP3A in the human hepatocytes than was previously shown in cultured rat hepatocytes. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Steady-state levels of CYP3A3/4 mRNA were increased by both ethanol and isopentanol. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | Ethanol and isopentanol induced immunoreactive CYP3A to a greater extent than did phenobarbital. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 8 | In one human hepatocyte culture, the lowest concentration of isopentanol tested increased CYP3A protein to an amount similar to that increased by rifampicin. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 9 | In another human hepatocyte culture, however, the amount of immunoreactive CYP3A increased by isopentanol was less than that increased by rifampicin. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 10 | In this latter culture, the steady-state levels of CYP3A3/4 mRNA increased by 0.1 mM isopentanol and 1 microM rifampicin were similar. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 11 | This is the first finding of induction of CYP3A in human hepatocytes by ethanol or isopentanol. | isopentyl alcohol | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |