Protein Name cytochrome P450 family 2 subfamily E member 1
Organism Homo sapiens
Gene ID 1571
Gene Symbol

CYP2E1

UniProt P05181 (CP2E1_HUMAN)
Relationships Total Number of functionally related compound(s) : 990
Total Number of Articles : 1531
Description

cytochrome P450 family 2 subfamily E member 1

Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

synonyms
  • cytochrome P450 2E1
  • 4-nitrophenol 2-hydroxylase
  • CYPIIE1
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Properties