Pub. Date : 2020
PMID : 33132314
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of germacrone on organic cation transporter 2 (OCT2) which is a transporter responsible for cisplatin uptake was determined. | germacrone | solute carrier family 22 member 2 | Homo sapiens |
| 2 | The effect of germacrone on organic cation transporter 2 (OCT2) which is a transporter responsible for cisplatin uptake was determined. | germacrone | solute carrier family 22 member 2 | Homo sapiens |
| 3 | Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate (3H-MPP+) uptake with IC50 of 15 microM with less effect on OCT1. | germacrone | solute carrier family 22 member 2 | Homo sapiens |
| 4 | Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate (3H-MPP+) uptake with IC50 of 15 microM with less effect on OCT1. | germacrone | solute carrier family 22 member 1 | Homo sapiens |
| 5 | In conclusion, germacrone prevents cisplatin-induced toxicity in renal proximal tubular cells via inhibition OCT2 transport function and reducing cisplatin accumulation. | germacrone | solute carrier family 22 member 2 | Homo sapiens |