Pub. Date : 2019
PMID : 31551777
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, in vitro studies show that HCPT significantly inhibits fibroblast proliferation and induces apoptosis by reducing the expression of extracellular matrix (ECM) proteins COL3A1 and alpha-smooth muscle actin (alpha-SMA). | 10-hydroxycamptothecin | collagen type III alpha 1 chain | Rattus norvegicus |
| 2 | In addition, in vitro studies show that HCPT significantly inhibits fibroblast proliferation and induces apoptosis by reducing the expression of extracellular matrix (ECM) proteins COL3A1 and alpha-smooth muscle actin (alpha-SMA). | 10-hydroxycamptothecin | actin gamma 2, smooth muscle | Rattus norvegicus |
| 3 | In addition, in vitro studies show that HCPT significantly inhibits fibroblast proliferation and induces apoptosis by reducing the expression of extracellular matrix (ECM) proteins COL3A1 and alpha-smooth muscle actin (alpha-SMA). | 10-hydroxycamptothecin | actin gamma 2, smooth muscle | Rattus norvegicus |
| 4 | Finally, we employed small interfering RNA (siRNA) to target inositol requiring kinase 1 (IRE1) and activated transcription factor 6 (ATF-6) to verify that the effect of inhibitory fibrosis of HCPT disappears after knockdown of ATF-6 and IRE1, thereby suggesting that an anti-fibrotic effect of HCPT is mediated by the ER-dependent apoptotic pathway. | 10-hydroxycamptothecin | activating transcription factor 6 | Rattus norvegicus |