PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31551777-10	2019	In addition, in vitro studies show that HCPT significantly inhibits fibroblast proliferation and induces apoptosis by reducing the expression of extracellular matrix (ECM) proteins COL3A1 and alpha-smooth muscle actin (alpha-SMA).	10-hydroxycamptothecin	40-44	collagen type III alpha 1 chain	Rattus norvegicus	181-187	
31551777-10	2019	In addition, in vitro studies show that HCPT significantly inhibits fibroblast proliferation and induces apoptosis by reducing the expression of extracellular matrix (ECM) proteins COL3A1 and alpha-smooth muscle actin (alpha-SMA).	10-hydroxycamptothecin	40-44	actin gamma 2, smooth muscle	Rattus norvegicus	192-217	
31551777-10	2019	In addition, in vitro studies show that HCPT significantly inhibits fibroblast proliferation and induces apoptosis by reducing the expression of extracellular matrix (ECM) proteins COL3A1 and alpha-smooth muscle actin (alpha-SMA).	10-hydroxycamptothecin	40-44	actin gamma 2, smooth muscle	Rattus norvegicus	219-228	
31551777-11	2019	Finally, we employed small interfering RNA (siRNA) to target inositol requiring kinase 1 (IRE1) and activated transcription factor 6 (ATF-6) to verify that the effect of inhibitory fibrosis of HCPT disappears after knockdown of ATF-6 and IRE1, thereby suggesting that an anti-fibrotic effect of HCPT is mediated by the ER-dependent apoptotic pathway.	10-hydroxycamptothecin	193-197	activating transcription factor 6	Rattus norvegicus	228-233