Title : Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia.

Pub. Date : 2019 Nov

PMID : 30819918






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bim, and c-Myc. CUDC-907 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bim, and c-Myc. CUDC-907 BCL2 like 11 Homo sapiens
3 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bim, and c-Myc. CUDC-907 MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 Downregulation of CHK1, Wee1, and RRM1, and induction of DNA damage also contributed to CUDC-907-induced apoptosis of acute myeloid leukemia cells. CUDC-907 checkpoint kinase 1 Homo sapiens
5 Downregulation of CHK1, Wee1, and RRM1, and induction of DNA damage also contributed to CUDC-907-induced apoptosis of acute myeloid leukemia cells. CUDC-907 WEE1 G2 checkpoint kinase Homo sapiens
6 Downregulation of CHK1, Wee1, and RRM1, and induction of DNA damage also contributed to CUDC-907-induced apoptosis of acute myeloid leukemia cells. CUDC-907 ribonucleotide reductase catalytic subunit M1 Homo sapiens