Pub. Date : 2017 May 4
PMID : 28473727
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKalpha1/2-LKB1. | cryptolepine | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKalpha1/2-LKB1. | cryptolepine | serine/threonine kinase 11 | Homo sapiens |
| 3 | The inhibitory effect of cryptolepine was associated with loss of mitochondrial membrane potential and reduced protein expression of Mfn1, Mfn2, Opa1 and p-Drp1 leading to disruption of mitochondrial dynamics. | cryptolepine | mitofusin 1 | Homo sapiens |
| 4 | The inhibitory effect of cryptolepine was associated with loss of mitochondrial membrane potential and reduced protein expression of Mfn1, Mfn2, Opa1 and p-Drp1 leading to disruption of mitochondrial dynamics. | cryptolepine | mitofusin 2 | Homo sapiens |
| 5 | The inhibitory effect of cryptolepine was associated with loss of mitochondrial membrane potential and reduced protein expression of Mfn1, Mfn2, Opa1 and p-Drp1 leading to disruption of mitochondrial dynamics. | cryptolepine | OPA1 mitochondrial dynamin like GTPase | Homo sapiens |
| 6 | Decreased expression of SDH-A and COX-I demonstrated that cryptolepine treatment reduced mitochondrial biogenesis. | cryptolepine | succinate dehydrogenase complex flavoprotein subunit A | Homo sapiens |