Protein Name succinate dehydrogenase complex flavoprotein subunit A
Organism Homo sapiens
Gene ID 6389
Gene Symbol

SDHA

UniProt P31040 (SDHA_HUMAN), D6RFM5 (D6RFM5_HUMAN), A0A024QZ30 (A0A024QZ30_HUMAN)
Relationships Total Number of functionally related compound(s) : 58
Total Number of Articles : 55
Description

succinate dehydrogenase complex flavoprotein subunit A

Gene Summary

This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

synonyms
  • succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
  • flavoprotein subunit of complex II
  • malate dehydrogenase [quinone] flavoprotein subunit
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Properties