Pub. Date : 2014
PMID : 25314304
15 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-kappaB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. | PQQ Cofactor | mitogen-activated protein kinase 14 | Mus musculus | ||
2 | Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-kappaB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. | PQQ Cofactor | mitogen-activated protein kinase 8 | Mus musculus | ||
3 | Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-kappaB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. | PQQ Cofactor | mitogen-activated protein kinase 14 | Mus musculus | ||
4 | Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-kappaB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. | PQQ Cofactor | mitogen-activated protein kinase 8 | Mus musculus | ||
5 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | nitric oxide synthase 2, inducible | Mus musculus | ||
6 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | cytochrome c oxidase II, mitochondrial | Mus musculus | ||
7 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | tumor necrosis factor | Mus musculus | ||
8 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | interleukin 1 beta | Mus musculus | ||
9 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | interleukin 6 | Mus musculus | ||
10 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | mast cell protease 1 | Mus musculus | ||
11 | Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells. | PQQ Cofactor | chemokine (C-C motif) ligand 3 | Mus musculus | ||
12 | The nuclear translocation of NF-kappaB and the phosphorylation level of p65, p38 and JNK MAP kinase pathways were also inhibited by PQQ in LPS stimulated primary microglia cells. | PQQ Cofactor | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus | ||
13 | The nuclear translocation of NF-kappaB and the phosphorylation level of p65, p38 and JNK MAP kinase pathways were also inhibited by PQQ in LPS stimulated primary microglia cells. | PQQ Cofactor | mitogen-activated protein kinase 14 | Mus musculus | ||
14 | The nuclear translocation of NF-kappaB and the phosphorylation level of p65, p38 and JNK MAP kinase pathways were also inhibited by PQQ in LPS stimulated primary microglia cells. | PQQ Cofactor | mitogen-activated protein kinase 8 | Mus musculus | ||
15 | Mice treated with PQQ demonstrated marked attenuation of neuroinflammation based on Western blotting and immunohistochemistry analysis of Iba1-against antibody in the brain tissue. | PQQ Cofactor | induction of brown adipocytes 1 | Mus musculus |