Protein Name mitogen-activated protein kinase 8
Organism Mus musculus
Gene ID 26419
Gene Symbol


UniProt Q91Y86 (MK08_MOUSE), Q7TSJ7 (Q7TSJ7_MOUSE), A6P3E4 (A6P3E4_MOUSE), G3X8U9 (G3X8U9_MOUSE), Q544A0 (Q544A0_MOUSE)
Relationships Total Number of functionally related compound(s) : 1537
Total Number of Articles : 2701

mitogen-activated protein kinase 8

Gene Summary

Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

  • mitogen-activated protein kinase 8
  • JNK1 beta1 protein kinase
  • MAP kinase 8
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