Pub. Date : 1988 Apr
PMID : 2451866
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo metabolism of CCl4 by rats pretreated with chlordecone, mirex, or phenobarbital. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | The propensity of chlordecone (CD) to potentiate hepatotoxic and lethal effects of CCl4 is well established. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | The propensity of chlordecone (CD) to potentiate hepatotoxic and lethal effects of CCl4 is well established. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | The purpose of this study was to test the possibility that CD potentiates the toxicity of CCl4 by increasing the metabolism of CCl4 to a greater degree than either PB or M. We compared the in vivo metabolism of CCl4 in rats pretreated with CD, M, or PB, by measuring the hepatic content of 14CCl4, the expiration of 14CCl4, expiration of 14CCl4-derived 14CO2, and lipid peroxidation. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | The purpose of this study was to test the possibility that CD potentiates the toxicity of CCl4 by increasing the metabolism of CCl4 to a greater degree than either PB or M. We compared the in vivo metabolism of CCl4 in rats pretreated with CD, M, or PB, by measuring the hepatic content of 14CCl4, the expiration of 14CCl4, expiration of 14CCl4-derived 14CO2, and lipid peroxidation. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 6 | The purpose of this study was to test the possibility that CD potentiates the toxicity of CCl4 by increasing the metabolism of CCl4 to a greater degree than either PB or M. We compared the in vivo metabolism of CCl4 in rats pretreated with CD, M, or PB, by measuring the hepatic content of 14CCl4, the expiration of 14CCl4, expiration of 14CCl4-derived 14CO2, and lipid peroxidation. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 7 | Expiration of 14CO2 measured during the 6 hr after CCl4 administration was increased in animals pretreated with PB or CD. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 8 | These data indicate that a single oral administration of CD (10 mg/kg) 24 hr prior to CCl4 administration (100 microliter/kg) enhances the oxidative metabolism of CCl4 but to a lesser extent than PB (80 mg/kg, ip, twice), which is in inverse relationship to the potentiation of the hepatotoxic and lethal effects of CCl4 associated with these pretreatments. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 9 | These data indicate that a single oral administration of CD (10 mg/kg) 24 hr prior to CCl4 administration (100 microliter/kg) enhances the oxidative metabolism of CCl4 but to a lesser extent than PB (80 mg/kg, ip, twice), which is in inverse relationship to the potentiation of the hepatotoxic and lethal effects of CCl4 associated with these pretreatments. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |