Pub. Date : 2013 May
PMID : 23386687
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis. | INK128 | mechanistic target of rapamycin kinase | Mus musculus |
| 2 | Marked reduction in activation of mTOR complex (mTORC)1 and blockade of cell growth was seen with both drugs, whereas only MLN0128 treatment had effects in blocking mTORC2 and 4EBP1 phosphorylation. | INK128 | CREB regulated transcription coactivator 2 | Mus musculus |
| 3 | Marked reduction in activation of mTOR complex (mTORC)1 and blockade of cell growth was seen with both drugs, whereas only MLN0128 treatment had effects in blocking mTORC2 and 4EBP1 phosphorylation. | INK128 | eukaryotic translation initiation factor 4E binding protein 1 | Mus musculus |
| 4 | Differences in side-effect profiles might make MLN0128 more attractive for treatment of patients with TSC-related tumors, but will require additional study in humans. | INK128 | TSC complex subunit 1 | Mus musculus |