PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23386687-0 2013 Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis. INK128 77-84 mechanistic target of rapamycin kinase Mus musculus 45-49 23386687-7 2013 Marked reduction in activation of mTOR complex (mTORC)1 and blockade of cell growth was seen with both drugs, whereas only MLN0128 treatment had effects in blocking mTORC2 and 4EBP1 phosphorylation. INK128 123-130 CREB regulated transcription coactivator 2 Mus musculus 165-171 23386687-7 2013 Marked reduction in activation of mTOR complex (mTORC)1 and blockade of cell growth was seen with both drugs, whereas only MLN0128 treatment had effects in blocking mTORC2 and 4EBP1 phosphorylation. INK128 123-130 eukaryotic translation initiation factor 4E binding protein 1 Mus musculus 176-181 23386687-10 2013 Differences in side-effect profiles might make MLN0128 more attractive for treatment of patients with TSC-related tumors, but will require additional study in humans. INK128 47-54 TSC complex subunit 1 Mus musculus 102-105