Pub. Date : 2011 Dec 1
PMID : 21903092
17 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. | Acecainide | small NF90 (ILF3) associated RNA E | Homo sapiens |
| 2 | Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. | Acecainide | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. | Acecainide | tumor protein p53 | Homo sapiens |
| 4 | We found earlier that NAPA represents an anti-apoptotic protein that promotes resistance to cisplatin in cancer cells by inducing the degradation of the tumor suppressor p53. | Acecainide | tumor protein p53 | Homo sapiens |
| 5 | In the present study, we investigated the cellular mechanism underlying the degradation of p53 by NAPA. | Acecainide | tumor protein p53 | Homo sapiens |
| 6 | Knockdown of NAPA using short-hairpin RNA was shown to induce p53 accumulation and to sensitize HEK293 cells to cisplatin. | Acecainide | tumor protein p53 | Homo sapiens |
| 7 | Expression of exogenous p53 in H1299 cells was increased following knockdown of NAPA and these cells showed increased sensitivity to cisplatin-induced apoptosis. | Acecainide | tumor protein p53 | Homo sapiens |
| 8 | Notably, knockdown of NAPA induced the ubiquitination and degradation of the E3 ubiquitin ligase synoviolin and the accumulation of p53 in unstressed HEK293 cells. | Acecainide | tumor protein p53 | Homo sapiens |
| 9 | Conversely, NAPA overexpression decreased the ubiquitination and degradation of synoviolin, and reduced p53 protein level. | Acecainide | tumor protein p53 | Homo sapiens |
| 10 | Knockdown of NAPA disrupted the interaction between synoviolin and proteins that form the endoplasmic reticulum-associated degradation (ERAD) complex and in turn decreased the ability of this complex to ubiquitinate p53. | Acecainide | tumor protein p53 | Homo sapiens |
| 11 | In addition, knockdown of NAPA induced the activation of the MAPK kinases ERK, JNK and p38, but only inhibition of ERK reduced synoviolin ubiquitination and p53 accumulation. | Acecainide | mitogen-activated protein kinase 3 | Homo sapiens |
| 12 | In addition, knockdown of NAPA induced the activation of the MAPK kinases ERK, JNK and p38, but only inhibition of ERK reduced synoviolin ubiquitination and p53 accumulation. | Acecainide | mitogen-activated protein kinase 1 | Homo sapiens |
| 13 | In addition, knockdown of NAPA induced the activation of the MAPK kinases ERK, JNK and p38, but only inhibition of ERK reduced synoviolin ubiquitination and p53 accumulation. | Acecainide | mitogen-activated protein kinase 8 | Homo sapiens |
| 14 | In addition, knockdown of NAPA induced the activation of the MAPK kinases ERK, JNK and p38, but only inhibition of ERK reduced synoviolin ubiquitination and p53 accumulation. | Acecainide | mitogen-activated protein kinase 1 | Homo sapiens |
| 15 | In addition, knockdown of NAPA induced the activation of the MAPK kinases ERK, JNK and p38, but only inhibition of ERK reduced synoviolin ubiquitination and p53 accumulation. | Acecainide | tumor protein p53 | Homo sapiens |
| 16 | These results indicate that NAPA promotes resistance to cisplatin through synoviolin and the ERAD complex which together induce the degradation of p53 and thus prevent apoptosis. | Acecainide | tumor protein p53 | Homo sapiens |
| 17 | Based on these findings, we propose that the combination of cisplatin and knockdown of NAPA represents a novel and attractive strategy to eradicate p53-sensitive cancer cells. | Acecainide | tumor protein p53 | Homo sapiens |