Pub. Date : 2008 Sep
PMID : 18296682
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transfection of cells with dominant-negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | In addition, naringin treatment strongly induced p21WAF1 expression, independent of the p53 pathway, and downregulated expression of cyclins and cyclin dependent kinases (CDKs). | naringin | tumor protein p53 | Homo sapiens |
| 3 | In addition, naringin treatment strongly induced p21WAF1 expression, independent of the p53 pathway, and downregulated expression of cyclins and cyclin dependent kinases (CDKs). | naringin | cyclin dependent kinase 2 | Homo sapiens |
| 4 | Moreover, treatment with naringin induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Moreover, treatment with naringin induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Moreover, treatment with naringin induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase. | naringin | mitogen-activated protein kinase 14 | Homo sapiens |
| 7 | Consistently, blockade of ERK function reversed naringin-mediated inhibition of cell proliferation and decreased cell-cycle proteins. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | Transfection of cells with dominant-negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |
| 9 | Transfection of cells with dominant-negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |
| 10 | Finally, the naringin-induced reduction in cell proliferation and cell-cycle proteins also was abolished in the presence of RasN17 and RafS621A mutant genes. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |
| 11 | These data demonstrate that the Ras/Raf/ERK pathway participates in p21WAF1 induction, subsequently leading to a decrease in the levels of cyclin D1/CDK4 and cyclin E-CDK2 complexes and naringin-dependent inhibition of cell growth. | naringin | zinc fingers and homeoboxes 2 | Homo sapiens |
| 12 | These data demonstrate that the Ras/Raf/ERK pathway participates in p21WAF1 induction, subsequently leading to a decrease in the levels of cyclin D1/CDK4 and cyclin E-CDK2 complexes and naringin-dependent inhibition of cell growth. | naringin | mitogen-activated protein kinase 1 | Homo sapiens |