Title : Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK.

Pub. Date : 2006 Oct

PMID : 16921400






8 Functional Relationships(s)
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Protein Name
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1 Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. delphinidin vascular endothelial growth factor A Homo sapiens
2 Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. delphinidin mitogen-activated protein kinase 1 Homo sapiens
3 Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. delphinidin mitogen-activated protein kinase 3 Homo sapiens
4 Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. delphinidin mitogen-activated protein kinase 8 Homo sapiens
5 KEY RESULTS: The inhibitory effect of RWPs on PDGF(AB)-induced release of VEGF was mimicked by delphinidin but not by quercetin, catechins, resveratrol, gallic acid or caffeic acid. delphinidin vascular endothelial growth factor A Homo sapiens
6 In the anthocyanin class, not only delphinidin but also cyanidin prevented VEGF release whereas malvidin and peonidin were without effect. delphinidin vascular endothelial growth factor A Homo sapiens
7 Although the p38 MAPK, ERK1/2 and JNK pathways have been involved in the PDGF(AB)-induced expression of VEGF, in our experiments, only phosphorylation of p38 MAPK and JNK was inhibited by RWPs, delphinidin and cyanidin. delphinidin vascular endothelial growth factor A Homo sapiens
8 Although the p38 MAPK, ERK1/2 and JNK pathways have been involved in the PDGF(AB)-induced expression of VEGF, in our experiments, only phosphorylation of p38 MAPK and JNK was inhibited by RWPs, delphinidin and cyanidin. delphinidin mitogen-activated protein kinase 8 Homo sapiens