Pub. Date : 2006 May
PMID : 16501007
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These results indicated that multiple hepatic P450s including CYP1A2, CYP2D6, and CYP3A4 participate in rutaecarpine hydroxylations. | rutecarpine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | These results indicated that multiple hepatic P450s including CYP1A2, CYP2D6, and CYP3A4 participate in rutaecarpine hydroxylations. | rutecarpine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | These results indicated that multiple hepatic P450s including CYP1A2, CYP2D6, and CYP3A4 participate in rutaecarpine hydroxylations. | rutecarpine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Among recombinant P450s, CYP1A1 had the highest rutaecarpine hydroxylation activity. | rutecarpine | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | CYP1A1-catalyzed rutaecarpine hydroxylations had V(max) values of 1,388 to approximately 1,893 pmol/min/nmol P450, K(m) values of 4.1 to approximately 9.5 microM, and K(i) values of 45 to approximately 103 microM. | rutecarpine | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1, CYP1A2, and CYP1B1 activities with respective IC(50) values of 2.56 +/- 0.04, 2.57 +/- 0.11, and 0.09 +/- 0.01 microM, suggesting that product inhibition might occur during rutaecarpine hydroxylation. | rutecarpine | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 7 | The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1, CYP1A2, and CYP1B1 activities with respective IC(50) values of 2.56 +/- 0.04, 2.57 +/- 0.11, and 0.09 +/- 0.01 microM, suggesting that product inhibition might occur during rutaecarpine hydroxylation. | rutecarpine | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 8 | The major metabolite 10-hydroxyrutaecarpine decreased CYP1A1, CYP1A2, and CYP1B1 activities with respective IC(50) values of 2.56 +/- 0.04, 2.57 +/- 0.11, and 0.09 +/- 0.01 microM, suggesting that product inhibition might occur during rutaecarpine hydroxylation. | rutecarpine | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |