Protein Name cytochrome P450 family 1 subfamily A member 1
Organism Homo sapiens
Gene ID 1543
Gene Symbol


UniProt P04798 (CP1A1_HUMAN), A0N0X8 (A0N0X8_HUMAN), E7EMT5 (E7EMT5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1459
Total Number of Articles : 2122

cytochrome P450 family 1 subfamily A member 1

Gene Summary

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

  • cytochrome P450 1A1
  • aryl hydrocarbon hydroxylase
  • cytochrome P1-450, dioxin-inducible
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