Protein Name cytochrome P450 family 1 subfamily A member 2
Organism Homo sapiens
Gene ID 1544
Gene Symbol


UniProt P05177 (CP1A2_HUMAN)
Relationships Total Number of functionally related compound(s) : 1532
Total Number of Articles : 2205

cytochrome P450 family 1 subfamily A member 2

Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

  • cytochrome P450 1A2
  • P450 form 4
  • aryl hydrocarbon hydroxylase
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