Pub. Date : 1992
PMID : 1284994
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | Our earlier histomorphometric and biochemical studies suggested that the progressive phase of the interactive toxicity of chlordecone (CD) + CCl4 involves suppression of hepatocellular regeneration. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | Dietary 10 ppm CD potentiated the hepatotoxicity of CCl4 to a greater extent than PB or M, as evidenced by elevations in plasma enzymes. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | Actual liver injury by CCl4 was greater in PB- than in CD-pretreated rats, as evidenced by histopathological observations. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | A 100% mortality occurred in CD-pretreated rats at 60 hr after CCl4 administration, whereas no mortality occurred in either N-, M-, or PB-pretreated rats, indicating recovery from liver injury. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 6 | Hepatocellular nuclear DNA levels were significantly decreased starting at 6 hr after CCl4 administration to CD-pretreated rats, but not in M- or PB-pretreated rats. | Chlordecone | C-C motif chemokine ligand 4 | Rattus norvegicus |