Pub. Date : 2001 Feb 15
PMID : 11181682
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: Oral bioavailability of docetaxel is very low, which is, at least in part, due to its affinity for the intestinal drug efflux pump P-glycoprotein (P-gp). | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | PURPOSE: Oral bioavailability of docetaxel is very low, which is, at least in part, due to its affinity for the intestinal drug efflux pump P-glycoprotein (P-gp). | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In addition, metabolism of docetaxel by cytochrome P450 (CYP) 3A4 in gut and liver may also contribute. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The purpose of this study was to enhance the systemic exposure to oral docetaxel on coadministration of cyclosporine (CsA), an efficacious inhibitor of P-gp and substrate for CYP 3A4. | Docetaxel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The purpose of this study was to enhance the systemic exposure to oral docetaxel on coadministration of cyclosporine (CsA), an efficacious inhibitor of P-gp and substrate for CYP 3A4. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |