PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11181682-1 2001 PURPOSE: Oral bioavailability of docetaxel is very low, which is, at least in part, due to its affinity for the intestinal drug efflux pump P-glycoprotein (P-gp). Docetaxel 33-42 ATP binding cassette subfamily B member 1 Homo sapiens 140-154 11181682-1 2001 PURPOSE: Oral bioavailability of docetaxel is very low, which is, at least in part, due to its affinity for the intestinal drug efflux pump P-glycoprotein (P-gp). Docetaxel 33-42 ATP binding cassette subfamily B member 1 Homo sapiens 156-160 11181682-2 2001 In addition, metabolism of docetaxel by cytochrome P450 (CYP) 3A4 in gut and liver may also contribute. Docetaxel 27-36 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 40-65 11181682-3 2001 The purpose of this study was to enhance the systemic exposure to oral docetaxel on coadministration of cyclosporine (CsA), an efficacious inhibitor of P-gp and substrate for CYP 3A4. Docetaxel 71-80 ATP binding cassette subfamily B member 1 Homo sapiens 152-156 11181682-3 2001 The purpose of this study was to enhance the systemic exposure to oral docetaxel on coadministration of cyclosporine (CsA), an efficacious inhibitor of P-gp and substrate for CYP 3A4. Docetaxel 71-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 175-182