Pub. Date : 2000 Jun 15
PMID : 10843709
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. | Resveratrol | tumor necrosis factor | Homo sapiens |
2 | Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. | Resveratrol | nuclear factor kappa B subunit 1 | Homo sapiens |
3 | Resveratrol blocked TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. | Resveratrol | tumor necrosis factor | Homo sapiens |
4 | Resveratrol also suppressed TNF-induced phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB, and NF-kappaB-dependent reporter gene transcription. | Resveratrol | tumor necrosis factor | Homo sapiens |
5 | Resveratrol also suppressed TNF-induced phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB, and NF-kappaB-dependent reporter gene transcription. | Resveratrol | RELA proto-oncogene, NF-kB subunit | Homo sapiens |
6 | Suppression of TNF-induced NF-kappaB activation by resveratrol was not restricted to myeloid cells (U-937); it was also observed in lymphoid (Jurkat) and epithelial (HeLa and H4) cells. | Resveratrol | tumor necrosis factor | Homo sapiens |
7 | Resveratrol also blocked NF-kappaB activation induced by PMA, LPS, H2O2, okadaic acid, and ceramide. | Resveratrol | interferon regulatory factor 6 | Homo sapiens |
8 | Resveratrol also inhibited the TNF-induced activation of mitogen-activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF-induced cytotoxicity and caspase activation. | Resveratrol | tumor necrosis factor | Homo sapiens |
9 | Resveratrol also inhibited the TNF-induced activation of mitogen-activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF-induced cytotoxicity and caspase activation. | Resveratrol | tumor necrosis factor | Homo sapiens |
10 | Both reactive oxygen intermediate generation and lipid peroxidation induced by TNF were suppressed by resveratrol. | Resveratrol | tumor necrosis factor | Homo sapiens |
11 | Resveratrol"s anticarcinogenic, anti-inflammatory, and growth-modulatory effects may thus be partially ascribed to the inhibition of activation of NF-kappaB and AP-1 and the associated kinases. | Resveratrol | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |