PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10843709-0 2000 Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. Resveratrol 0-11 tumor necrosis factor Homo sapiens 23-26 10843709-0 2000 Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. Resveratrol 0-11 nuclear factor kappa B subunit 1 Homo sapiens 79-110 10843709-4 2000 Resveratrol blocked TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. Resveratrol 0-11 tumor necrosis factor Homo sapiens 20-23 10843709-5 2000 Resveratrol also suppressed TNF-induced phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB, and NF-kappaB-dependent reporter gene transcription. Resveratrol 0-11 tumor necrosis factor Homo sapiens 28-31 10843709-5 2000 Resveratrol also suppressed TNF-induced phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB, and NF-kappaB-dependent reporter gene transcription. Resveratrol 0-11 RELA proto-oncogene, NF-kB subunit Homo sapiens 89-113 10843709-6 2000 Suppression of TNF-induced NF-kappaB activation by resveratrol was not restricted to myeloid cells (U-937); it was also observed in lymphoid (Jurkat) and epithelial (HeLa and H4) cells. Resveratrol 51-62 tumor necrosis factor Homo sapiens 15-18 10843709-7 2000 Resveratrol also blocked NF-kappaB activation induced by PMA, LPS, H2O2, okadaic acid, and ceramide. Resveratrol 0-11 interferon regulatory factor 6 Homo sapiens 62-65 10843709-9 2000 Resveratrol also inhibited the TNF-induced activation of mitogen-activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF-induced cytotoxicity and caspase activation. Resveratrol 0-11 tumor necrosis factor Homo sapiens 31-34 10843709-9 2000 Resveratrol also inhibited the TNF-induced activation of mitogen-activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF-induced cytotoxicity and caspase activation. Resveratrol 0-11 tumor necrosis factor Homo sapiens 139-142 10843709-10 2000 Both reactive oxygen intermediate generation and lipid peroxidation induced by TNF were suppressed by resveratrol. Resveratrol 102-113 tumor necrosis factor Homo sapiens 79-82 10843709-11 2000 Resveratrol"s anticarcinogenic, anti-inflammatory, and growth-modulatory effects may thus be partially ascribed to the inhibition of activation of NF-kappaB and AP-1 and the associated kinases. Resveratrol 0-11 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 161-165