Title : Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.

Pub. Date : 1994 Jan 7

PMID : 8276809






1 Functional Relationships(s)
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1 These data support the hypothesis that binding of tyrosyl-phosphorylated receptors to p85 SH2 domains is a general mechanism for PtdIns 3"-kinase activation, and they suggest that direct interactions between the insulin receptor and PtdIns 3"-kinase may provide an alternative pathway for the activation of this enzyme by insulin. cyclo(tyrosyl-tyrosyl) insulin receptor Homo sapiens