PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8276809-8 1994 These data support the hypothesis that binding of tyrosyl-phosphorylated receptors to p85 SH2 domains is a general mechanism for PtdIns 3"-kinase activation, and they suggest that direct interactions between the insulin receptor and PtdIns 3"-kinase may provide an alternative pathway for the activation of this enzyme by insulin. cyclo(tyrosyl-tyrosyl) 50-57 insulin receptor Homo sapiens 212-228