Protein Name insulin receptor
Organism Homo sapiens
Gene ID 3643
Gene Symbol


UniProt P06213 (INSR_HUMAN)
Relationships Total Number of functionally related compound(s) : 748
Total Number of Articles : 1503

insulin receptor

Gene Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

  • insulin receptor
  • IR
  • CD220
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