Pub. Date : 2022 May 1
PMID : 35405526
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Our findings indicated that Ni fumes expose evoked aerobic glycolysis by AMPK/GOLPH3, while metformin attenuated Ni particles-promoted GOLPH3-mediated aerobic glycolysis by p-AMPK expression increase. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | The results indicated that metformin decreased the protein levels of GOLPH3, LDHA, HK2, MCT-4 and improved p-AMPK expression. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Thus, our findings demonstrated metformin antagonized Ni-refining fumes-caused aerobic glycolysis via AMPK/GOLPH3. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |