Pub. Date : 2021 Oct 1
PMID : 33654003
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: GWAS verified that CYP3A5*3 is the only common variant associated with TAC PK variability in Koreans. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | We detected several CYP3A5 and CYP3A4 rare variants which could potentially affect TAC metabolism. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | Gene-based association tests in the 61 absorption, distribution, metabolism, and excretion (ADME) genes revealed that CYP1A1 are associated with additional TAC PK variability: CYP1A1 rare variant carriers among CYP3A5 poor metabolizers showed lower TAC trough levels than the noncarrier controls. | Tacrolimus | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |