Protein Name cytochrome P450 family 3 subfamily A member 5
Organism Homo sapiens
Gene ID 1577
Gene Symbol


UniProt P20815 (CP3A5_HUMAN), B7Z3P6 (B7Z3P6_HUMAN)
Relationships Total Number of functionally related compound(s) : 539
Total Number of Articles : 1202

cytochrome P450 family 3 subfamily A member 5

Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

  • cytochrome P450 3A5
  • aryl hydrocarbon hydroxylase
  • cytochrome P450 HLp2
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