Pub. Date : 2021
PMID : 33361598
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer"s disease (AD), inhibiting amyloid-beta (Abeta) production and promoting Abeta clearance. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | BACKGROUND: Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer"s disease (AD), inhibiting amyloid-beta (Abeta) production and promoting Abeta clearance. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | BACKGROUND: Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer"s disease (AD), inhibiting amyloid-beta (Abeta) production and promoting Abeta clearance. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 4 | BACKGROUND: Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer"s disease (AD), inhibiting amyloid-beta (Abeta) production and promoting Abeta clearance. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 5 | This work focused on whether BBR regulates the production and clearance of ribosylation-induced Abeta pathology via inhibiting mTOR signaling. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 6 | OBJECTIVE: To explore whether BBR ameliorates ribosylation-induced Abeta pathology in APP/PS1 mice. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 7 | BBR reduces the activity of BACE1 and gamma-secretase induced by D-ribose, and enhances Abeta-degrading enzymes and Neprilysin, and inhibits the expression of Abeta in APP/PS1 mice. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 8 | BBR reduces the activity of BACE1 and gamma-secretase induced by D-ribose, and enhances Abeta-degrading enzymes and Neprilysin, and inhibits the expression of Abeta in APP/PS1 mice. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |
| 9 | CONCLUSION: BBR ameliorates ribosylation-induced Abeta pathology via inhibiting mTOR/p70S6K signaling and improves spatial learning and memory of the APP/PS1 mice. | Berberine | amyloid beta (A4) precursor protein | Mus musculus |