| Protein Name | amyloid beta precursor protein |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11820 |
| Gene Symbol | App |
| UniProt | P12023 (A4_MOUSE), Q3TWF3 (Q3TWF3_MOUSE), Q6GR78 (Q6GR78_MOUSE), A0A2I3BQZ9 (A0A2I3BQZ9_MOUSE), A0A2I3BPT1 (A0A2I3BPT1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
1407
Total Number of Articles : 2009 |
Description |
amyloid beta precursor protein |
| Gene Summary |
Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; nervous system development; and regulation of primary metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is active in cell surface; intracellular vesicle; and presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; metanephros; peripheral nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |