Pub. Date : 2021 May
PMID : 33069631
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic beta-cells via the PI3K/Akt/FoxO1 signaling pathway. | Saponins | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002. | Saponins | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. | Saponins | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic beta-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway. | Saponins | AKT serine/threonine kinase 1 | Rattus norvegicus |