PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33069631-0	2021	Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic beta-cells via the PI3K/Akt/FoxO1 signaling pathway.	Saponins	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	103-106	
33069631-8	2021	Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002.	Saponins	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	52-55	
33069631-10	2021	Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002.	Saponins	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	24-27	
33069631-13	2021	In conclusion, our findings improve our understanding of the function of saponins in INS-1 pancreatic beta-cells and suggest that saponins may increase insulin secretion via the PI3K/Akt/FoxO1 signaling pathway.	Saponins	130-138	AKT serine/threonine kinase 1	Rattus norvegicus	183-186