Title : Activation of AMPK/aPKCĪ¶/CREB pathway by metformin is associated with upregulation of GDNF and dopamine.

Pub. Date : 2020 Oct

PMID : 32800853






2 Functional Relationships(s)
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1 We further investigated the role of the neurotrophic factors in the activation of TH and observed that both BDNF and GDNF-induction were essential for metformin-induced TH activation. Metformin glial cell derived neurotrophic factor Homo sapiens
2 We found that the AMPK/aPKCzeta/CREB pathway was essential for metformin-induced GDNF upregulation and TH activation. Metformin glial cell derived neurotrophic factor Homo sapiens