PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32800853-6 2020 We further investigated the role of the neurotrophic factors in the activation of TH and observed that both BDNF and GDNF-induction were essential for metformin-induced TH activation. Metformin 151-160 glial cell derived neurotrophic factor Homo sapiens 117-121 32800853-7 2020 We found that the AMPK/aPKCzeta/CREB pathway was essential for metformin-induced GDNF upregulation and TH activation. Metformin 63-72 glial cell derived neurotrophic factor Homo sapiens 81-85