Protein Name glial cell derived neurotrophic factor
Organism Homo sapiens
Gene ID 2668
Gene Symbol


UniProt P39905 (GDNF_HUMAN), A0A0S2Z3V2 (A0A0S2Z3V2_HUMAN), A0A0S2Z3T2 (A0A0S2Z3T2_HUMAN)
Relationships Total Number of functionally related compound(s) : 388
Total Number of Articles : 636

glial cell derived neurotrophic factor

Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

  • glial cell line-derived neurotrophic factor
  • astrocyte-derived trophic factor
  • ATF
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