Title : Modulation of FLT3 through decitabine-activated C/EBPa-PU.1 signal pathway in FLT3-ITD positive cells.

Pub. Date : 2019 Dec

PMID : 31479709






7 Functional Relationships(s)
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1 Modulation of FLT3 through decitabine-activated C/EBPa-PU.1 signal pathway in FLT3-ITD positive cells. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens
2 Modulation of FLT3 through decitabine-activated C/EBPa-PU.1 signal pathway in FLT3-ITD positive cells. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens
3 This study aimed to examine the effect of decitabine (DAC) on FLT3-ITD positive AML. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens
4 This study aimed to examine the effect of decitabine (DAC) on FLT3-ITD positive AML. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens
5 In our study, we found that expression of FLT3 and its downstream targets was decreased in FLT3-ITD mutant cell lines treated with DAC. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens
6 In our study, we found that expression of FLT3 and its downstream targets was decreased in FLT3-ITD mutant cell lines treated with DAC. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens
7 These findings indicated that DAC upregulated PU.1 to induce downregulation of FLT3 to trigger apoptosis. Decitabine fms related receptor tyrosine kinase 3 Homo sapiens