Pub. Date : 2018 Mar
PMID : 29431743
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, sorafenib reduced expression of the transcription factor ATF4, thereby blocking negative regulation of interferon regulatory factor 7 (IRF7) activation, which enhanced IL-15 transcription. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 2 | Both IRF7 knockdown and ATF4 overexpression in leukemia cells antagonized sorafenib-induced IL-15 production in vitro. | Sorafenib | activating transcription factor 4 | Homo sapiens |
| 3 | Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans. | Sorafenib | activating transcription factor 4 | Homo sapiens |