Protein Name activating transcription factor 4
Organism Homo sapiens
Gene ID 468
Gene Symbol


UniProt P18848 (ATF4_HUMAN)
Relationships Total Number of functionally related compound(s) : 451
Total Number of Articles : 664

activating transcription factor 4

Gene Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

  • cyclic AMP-dependent transcription factor ATF-4
  • DNA-binding protein TAXREB67
  • cAMP response element-binding protein 2
Click to show/hide the synonyms