PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29431743-5	2018	Mechanistically, sorafenib reduced expression of the transcription factor ATF4, thereby blocking negative regulation of interferon regulatory factor 7 (IRF7) activation, which enhanced IL-15 transcription.	Sorafenib	17-26	activating transcription factor 4	Homo sapiens	74-78	
29431743-6	2018	Both IRF7 knockdown and ATF4 overexpression in leukemia cells antagonized sorafenib-induced IL-15 production in vitro.	Sorafenib	74-83	activating transcription factor 4	Homo sapiens	24-28	
29431743-9	2018	Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans.	Sorafenib	56-65	activating transcription factor 4	Homo sapiens	90-94