Title : Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.

Pub. Date : 2016 May 3

PMID : 26993769






3 Functional Relationships(s)
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1 The JNK and P38alpha pathways play a crucial role in tissue homeostasis, apoptosis and autophagy under genotoxic stresses, but it is unclear whether single nucleotide polymorphisms (SNPs) of genes in these pathways play a role in platinum-based chemotherapy-induced toxicities in patients with advanced non-small cell lung cancer (NSCLC). Platinum mitogen-activated protein kinase 8 Homo sapiens
2 We genotyped 11 selected, independent, potentially functional SNPs of nine genes in the JNK and P38alpha pathways in 689 patients with advanced NSCLC treated with platinum-combination chemotherapy regimens. Platinum mitogen-activated protein kinase 8 Homo sapiens
3 The present study provides evidence that genetic variants in genes involved in the JNK and P38alpha pathways may predict platinum-based chemotherapy toxicity outcomes in patients with advanced NSCLC. Platinum mitogen-activated protein kinase 8 Homo sapiens