PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26993769-1 2016 The JNK and P38alpha pathways play a crucial role in tissue homeostasis, apoptosis and autophagy under genotoxic stresses, but it is unclear whether single nucleotide polymorphisms (SNPs) of genes in these pathways play a role in platinum-based chemotherapy-induced toxicities in patients with advanced non-small cell lung cancer (NSCLC). Platinum 230-238 mitogen-activated protein kinase 8 Homo sapiens 4-7 26993769-2 2016 We genotyped 11 selected, independent, potentially functional SNPs of nine genes in the JNK and P38alpha pathways in 689 patients with advanced NSCLC treated with platinum-combination chemotherapy regimens. Platinum 163-171 mitogen-activated protein kinase 8 Homo sapiens 88-91 26993769-6 2016 The present study provides evidence that genetic variants in genes involved in the JNK and P38alpha pathways may predict platinum-based chemotherapy toxicity outcomes in patients with advanced NSCLC. Platinum 121-129 mitogen-activated protein kinase 8 Homo sapiens 83-86