Pub. Date : 2016 Jan 19
PMID : 26657295
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence. | Topotecan | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
2 | Importantly, TPT-treated senescent tumor cells act growth-inhibitory in a dose-dependent manner on non-senescent tumor cells and MYCN expression is significantly reduced in vitro and in vivo. | Topotecan | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |