Title : Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence.

Pub. Date : 2016 Jan 19

PMID : 26657295






2 Functional Relationships(s)
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1 Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence. Topotecan MYCN proto-oncogene, bHLH transcription factor Homo sapiens
2 Importantly, TPT-treated senescent tumor cells act growth-inhibitory in a dose-dependent manner on non-senescent tumor cells and MYCN expression is significantly reduced in vitro and in vivo. Topotecan MYCN proto-oncogene, bHLH transcription factor Homo sapiens