Pub. Date : 2015 Mar 15
PMID : 25609059
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: We confirm that both trabectedin and doxorubicin were able to strongly reduce EWS-FLI1 (both type I and type II) binding to two representative target genes (TGFbetaR2 and CD99), both in vitro and in xenografts. | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |
| 2 | However, trabectedin, but not doxorubicin, was also able to increase the occupancy of EWS-FLI1 to IGF1R promoters, leading to IGF1R upregulation. | Trabectedin | Fli-1 proto-oncogene, ETS transcription factor | Homo sapiens |