Protein Name | Fli-1 proto-oncogene, ETS transcription factor |
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Organism | Homo sapiens |
Gene ID | 2313 |
Gene Symbol | FLI1 |
UniProt | Q01543 (FLI1_HUMAN), A0A024R3K4 (A0A024R3K4_HUMAN), A0A024R3M5 (A0A024R3M5_HUMAN), A0A024R3N6 (A0A024R3N6_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
128
Total Number of Articles : 141 |
Description |
Fli-1 proto-oncogene, ETS transcription factor |
Gene Summary |
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
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