PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25609059-4 2015 RESULTS: We confirm that both trabectedin and doxorubicin were able to strongly reduce EWS-FLI1 (both type I and type II) binding to two representative target genes (TGFbetaR2 and CD99), both in vitro and in xenografts. Trabectedin 30-41 Fli-1 proto-oncogene, ETS transcription factor Homo sapiens 91-95 25609059-5 2015 However, trabectedin, but not doxorubicin, was also able to increase the occupancy of EWS-FLI1 to IGF1R promoters, leading to IGF1R upregulation. Trabectedin 9-20 Fli-1 proto-oncogene, ETS transcription factor Homo sapiens 90-94