Pub. Date : 2015 Feb 15
PMID : 25583361
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 2 | We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 3 | We investigated GnRH interactions with the His(7.36(305)) residue of the GnRH receptor, using functional and computational analysis of modified GnRH receptors and peptides. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 4 | Non-polar His(7.36(305)) substitutions decreased receptor affinity for GnRH four- to forty-fold, whereas GnRH signaling potency was more decreased (~150-fold). | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 5 | Uncharged polar His(7.36(305)) substitutions decreased GnRH potency, but not affinity. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 6 | [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 7 | [2-Nal(3)]-GnRH retained high affinity at receptors with non-polar His(7.36(305)) substitutions, supporting a role for His(7.36(305)) in recognizing Trp(3) of GnRH. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |
| 8 | Results suggest that His(7.36(305)) of the GnRH receptor forms two distinct interactions that determine binding to Trp(3) and couple agonist binding to the conserved transmembrane domain network that activates GPCRs. | Histidine | gonadotropin releasing hormone 1 | Homo sapiens |